Add to My favourites
The effect of CCHFv infection on epitelial and endothelial barriers
Research description:
Crimean-Congo hemorrhagic fever virus (CCHFv) is an emerging virus belonging to the family Bunyaviridae. CCHFv is the causative agent of severe hemorrhagic fever in humans. The dangerous nature of CCHFv has restricted research efforts to biosafety level-4 (BSL-4) laboratories. One of the most obvious symptoms in the virus hemorrhagic fever patients is bleeding from different organs, which could be explained by increased permeability of the endothelium. Recently it was demonstrated that filoviruses replicate in endothelial cell in vitro as well as in vitro, and the infected endothelial cells in organ or cell cultures show cell lysis. It is reasonable to assume that endothelial cell damage contribute to gross bleeding tendency during filovirus infection. We have recently found that CCHFv can infect human endothelial cells in vitro resulting in the production of infectious viral particles, but in contrast to filoviruses, CCHFv do not cause any cytopathogenic effect in this cell lines. We suggest that infection could cause dysfunction of the endothelium leading to the bleeding process. Thereby, we are interested to study how the CCHF virus infection increases the vesicular permeability in epithelial and endothelial cells.
Anne-marie C. Andersen (Master student)
Related groups:
Related navigation fields:
|