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Strategies to stimulate neutralizing antibodies against the HIV-1 envelope glycoproteins
Research description:
An effective preventative vaccine against HIV-1 will need to induce broadly neutralizing antibodies (nAb) against the viral envelope glycoproteins (Env). Induction of nAb against HIV-1 through vaccination has proven to be extremely difficult. Years of basic research aimed at characterizing the antigenic properties of Env demonstrate that HIV-1 is unusually well equipped to resist neutralization by antibodies. The evolving rationale in the field is that monomeric gp120 elicits predominantly non-neutralizing or strain-restricted (V3 loop primary sequence restricted antibodies). Immunogens that more closely mimic the desirable aspects of the functional viral spike complex therefore have a greater chance at eliciting broadly neutralizing antibodies. We are investigating how antibody responses against selected engineered HIV-1 Env immunogens can be optimized through the use of viral delivery systems or well-defined molecular adjuvants to generate long-lived neutralizing antibody responses.
Ph.D. student Mattias Forsell
Project student Christopher Ericsson
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