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The role of Innate immunity for controlling the crimean congo hemorraghic fever virus
Research description:
New disease agents are emerging in recent years, often as a result of ecological and environmental changes. After infection of their vertebrate hosts, viruses encounter a formidable task. They have to multiply in the face of a vigorous host immune response. One of the first obstacles is the interferon (IFN) system. Virus-infected cells synthesize and secrete interferons, which warn the body of the dangerous intruders. Secreted IFNs circulate in the body and cause susceptible cells to express potent antiviral mechanisms, which limit further viral growth and spread. The general aim of our projects is to study the role of innate immunity in controlling the emerging virus infection. The major focus is to study the antiviral mechanism of Interferon type I and II on virus replication cycle. A better understanding of virus host-cell interactions is necessary to design efficient strategies for disease control.
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