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Jonas Klingström, PhD
Phone: +46 8 457 25 07
Email: jonas.klingstrom@ki.se
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Karolinska Institutet
Research summary:
Klingström, J., A. Plyusnin, A. Vaheri and Å. Lundkvist.
Wild-type Puumala hantavirus infection induces cytokines, C-reactive protein, creatinine, and nitric oxide in cynomolgus macaques.
Journal of Virology 76:444-449. 2002.
Åkerström, S., M. Mousavi-Jazi, J. Klingström, M. Leijon, Å. Lundkvist and A. Mirazimi. Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome (SARS) Coronavirus. Journal of Virology 79:1966-1969. 2005.
Klingström, J., J. Hardestam, and Å. Lundkvist. Dobrava, but not Saaremaa, hantavirus is lethal and induces nitric oxide production in suckling mice. Microbes and Infection 8:728-737. 2006.
Klingström, J., L. Gudmundsdotter, B. Zuber, J. Hinkula, A. Mörner, B. Wahren, and E. Rollman.
Elevated levels of serum perforin in chronic HIV-1 and acute SIV/SHIV infection. AIDS 20:125-127. 2006.
Klingström, J., J. Hardestam, M. Stoltz, B. Zuber, Å. Lundkvist, S. Linder, and C. Ahlm. Loss of cell membrane integrity in Puumala hantavirus infected patients correlates with levels of epithelial cell apoptosis and perforin. Journal of Virology, in press. 2006. Åkerström, S., M. Mousavi-Jazi, J. Klingström, M. Leijon, Å. Lundkvist and A. Mirazimi. Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome (SARS) Coronavirus. Journal of Virology 79:1966-1969. 2005.
Klingström, J., L. Gudmundsdotter, B. Zuber, J. Hinkula, A. Mörner, B. Wahren, and E. Rollman. Elevated levels of serum perforin in chronic HIV-1 and acute SIV/SHIV infection. AIDS 20:125-127. 2006.
Klingström, J., J. Hardestam, and Å. Lundkvist. Dobrava, but not Saaremaa, hantavirus is lethal and induces nitric oxide production in suckling mice. Microbes and Infection 8:728-737. 2006.
Klingström, J., J. Hardestam, M. Stoltz, B. Zuber, Å. Lundkvist, S. Linder, and C. Ahlm. Loss of cell membrane integrity in Puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin. Journal of Virology, 80:8279-8282. 2006.
Klingström, J., S. Åkerström, J. Hardestam, M. Stoltz, M. Simon, K. I. Falk, A. Mirazimi, M. Rottenberg, and Å. Lundkvist. Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions. European Journal of Immunology, in press. 2006.
Methods:
Biosafety level 3 and 4-laboratories, Virus, Primary cells, ELISA, ELISPOT, FACS, Apoptosis
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