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Research projects and groups: Infection
This section describes the current research projects carried out by the members in the KI Infection Network.

Projects (210)

Research groups (24)

Page 1 of 11

Activating receptors on antigen presenting cells
Project leader: Jonas Sundbäck
We have cloned a novel receptor expressed on antigen presenting cells, including dendritic cells (DC), macrophages and B cells, that we have named triggering receptor expressed in antigen presenting cells (TRAPC). The receptor belongs to the TREM family of molecules and associates with DAP12 to ...

Activation of retrovirus for membrane fusion
Project leader: Henrik Garoff

A Japan-Sweden malaria venture net
Project leader: Akira Kaneko
Tracing the routes from mainland Africa to South-east Asia, Island Melanesia and Madagascar, we aim at a better understanding of how humans, parasites and mosquitoes have co-evolved over time and resulted in the diversity. We will provide a novel area-specific strategy in the malaria challenge of ...

Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
Project leader: Lei Lu

Amodiaquine resistant Plasmodium falciparum malaria and gene polymorphisms in Kenya.
Project leader: Gabrielle Holmgren

A pneumococcal pilus influences virulence and host inflammatory responses
Project leader: Birgitta Henriques-Normark

Are NK cells involved in HSV-1 reactivation?
Project leader: Louise Berg
That NK cells are important in the immune response to herpes virus infections has been best studied in murine cytomegalovirus infection, and the ability to control MCMV infection, as infection with herpes simplex virus (HSV), is genetically mapped to a locus coding for NK receptors. The role of NK ...

Bacterial adaptation to phagocytic cells
Project leader: Mikael Rhen
This project applies Salmonella enterica serovar Typhimurium (S. Typhimurium) as a model for studying the pathogenesis of bacterial intracellular infections. Apart from being a classical laboratory bacterium, S. Typhimurium actively enters a variety of host cells. In fact, S. Typhimurium causes in ...

Bacterial gene regulation and chronic infection
Project leader: Mikael Rhen
In Salmonella enterica serovar Typhimurium (S. Typhimurium), the expression of virulence factors is highly regulated. The bacteria appear capable of sensing alterations in environmental cues, and regulate the expression of virulence factors accordingly. Mutations that affect gene regulatory ...

Biology and immuno-recognition of antigens expressed on the P. falciparum-infected erythrocyte surface
Project leader: Qijun Chen

Burkitt´s lymphoma: PfEMP1 and Epstein-Barr virus
Project leader: Mats Wahlgren
In the present project we analyze the mechanisms by which chronic malaria infection affects the regulation of the B cell compartment and the relationship between EBV and B-lymphocytes. We have found that that malaria may join forces with EBV to heighten the risk for Burkitts lumphoma. P. falciparum ...

Buruli Ulcer- studies on wound pathogenesis and treament
Project leader: Sven Britton

Calcium and drug resistance in malaria parasites
Project leader: Akira Kaneko

Calcium Signaling and Drug Resistance in Malaria Parasites
Project leader: Per Uhlen
The overall goal of this project is to study the role of calcium (Ca2+) signaling for drug resistance in the human malaria parasite (Plasmodium falciparum). A major obstacle in today’s malaria control programs is the drug resistance which was developed to nearly all existent antimalarials used ...

Carcinogenic properties of the cytolethal distending toxin, the first bacterial genotoxin
Project leader: Javier Avila-Cariño
Cancer represents one of the major public health problems in our society. Knowledge derived from basic medical research has been essential for prevention and prophylaxis, development of treatments, and improved quality of life in patients. However, a more complex scenario is emerging where ...

CD4 function and HIV prognosis
Project leader: Hans Gaines

CD8 T cell effector function in mucosal tissues
Project leader: Máire Quigley

Cell-mediated immunity to influenza in stem cell transplant recipients
Project leader: Per Ljungman
Influenza is a severe infection after stem cell transplantation and the vaccination responses are frequently poor. Little is known about the cell-mediated responses to infection. Stem cell transplant recipients, their donors, and healthy controls are vaccinated and the specific T-cell response as ...

Characterization a conserved molecule expressed on the surface of the Plasmodium falciparum-infected erythrocyte
Project leader: Qijun Chen
Malaria parasites evade human immune clearance by antigenic variation. We have recently identified a conserved molecule which is expressed on the infected erythrocyte surface. Functional analysis of the molecule will provide important information of parasite biology and an ideal antigen for vaccine ...

Clonal success of piliated penicillin non-susceptible pneumococci
Project leader: Birgitta Henriques-Normark

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